Organic Acidemias are a group of inheritable genetic metabolic disorders in which there is a defect in protein metabolism where an essential enzyme is absent or malfunctioning. This defect results in a build up of chemicals, in this case usually acids, on one side of the metabolic blockage and a deficiency of vital chemicals on the other. This causes an overdosage of one chemical (often toxic) and the shortage of another which is essential to normal body functioning.
